Fexofenadine Hydrochloride tablet is a predominant human and animal active metabolite of terfenadine. It is selective histamine H1-receptor antagonist. There has been no evidence of local anesthetic, analgesic, anticonvulsant, antidepressant, antidopaminergic, antiserotonergic, anticholinergic, sedative, H2-receptor antagonist, or a1-adrenergic receptor blocking activity.
Fexofenadine inhibits histamine induced skin wheal and flare responses. Following single and twice daily oral dose administration, antihistaminic effects occur within 1 hour, achieve a maximum at 6 hours, and last a minimum of 12 hours. There is no evidence of tolerance to these effects after 28 days of dosing.
